The herpesvirus family is characterized by their structural
Components which include:
1.) envelope: which makes the viron appear pleomorphic, contains glycoprotein surfaces projections 8-10 nm long and has Fc receptors.
2.) tegument: amorphous globular material surrounding capsid.
3.) capsid: icosahedral geometry, 100-110 nm, with 162 capsomers and T = 16.
4.) core: contains ds DNA encircling a cylendrical spool of proteins.
Replication of herpesviruses takes place in the nucleus. More intersting sequential transcription and translation of early alpha, beta and gama genes (early genes regulate transcription of later genes) occurs to produce alpha, beta and gama proteins. The packaging of the virus involves head-full packaging and the envelope is acquired by budding through the nuclear membrane
Encapsidation and the assembly of viral particles occurs in the nucleus. Maturation of viral particles occurs by budding through the inner layer of two layered nuclear membrane. The viral particles are then transported across cytoplasm in vesicles. The envelope is acquired by fusing with the plasma membrane
CPE include cytocidal infection in permissive cells is
cytocidal and intranuclear inclusions,sometimes cytogmegalic cells or